Quantifying Peptide Signal in MALDI-TOF Mass Spectrometry Data
نویسندگان
چکیده
منابع مشابه
Quantifying peptide signal in MALDI-TOF mass spectrometry data.
This study addressed the question of which properties in MALDI-TOF spectra are relevant to the task of identifying mass and abundance of a peptide species in human serum. Data of this type are common to biomarker studies, but significant within- and between-spectrum variabilities make quantifying biologically induced features difficult. We investigated this signal content and quantified the exi...
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A new peak detection method has been developed for rapid selection of peptide and its fragment ion peaks for protein identification using tandem mass spectrometry. The algorithm applies classification of peak intensities present in the defined mass range to determine the noise level. A threshold is then given to select ion peaks according to the determined noise level in each mass range. This a...
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We present a software package for the analysis of MALDITOF mass spectrometry data. The software is designed to facilitate a complete exploratory workflow: pre-processing of raw spectral data, specification of study groups for comparison, statistical differential analysis, visualization of peptide peaks, and classification. The software supports various external tools for these tasks. We also pa...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2005
ISSN: 1535-9476
DOI: 10.1074/mcp.m500130-mcp200